Updates 02/24/2021
Test Updates
New NTRK reflex option being
added to select NeoTYPE® Solid Tumor Profiles
The majority of the NeoTYPE® Solid Tumor Profiles
include screening for NTRK rearrangements by Pan-TRK IHC followed by NTRK 1-3
fusion analysis by NGS when IHC is expressed or equivocal. Beginning Monday, March 8th
clients may choose reflex testing with the NTRK1-3 FISH Panel (global or
tech-only) instead of NTRK NGS Fusion Panel. This new option applies to the
following NeoTYPE® Profiles: Breast,
Colorectal,
Cervical,
Discovery,
Endometrial,
Esophageal,
GI
Predictive, Gastric,
Head
& Neck, Liver/Biliary,
Lung,
Melanoma,
Other
Solid Tumor, Ovarian,
Pancreas,
Precision,
and Thyroid.
- NTRK NGS fusion testing will remain the default method
as our RNA-based assay has very high sensitivity and specificity
(approaching 100%)
- Clinical impact of choosing FISH instead
- FISH results are faster, with reflexed FISH results
issued ~day 8 after receipt of the NeoTYPE® order compared to
~day 17 for reflexed NTRK NGS results
- FISH sensitivity is lower, detecting ~80% of the
translocations associated with NTRK 1-3
- Billing impact of choosing FISH instead
- Please substitute FISH CPT Codes (88374x3 automated or
88377x3 manual) for the NTRK NGS Fusion Panel CPT Code (81479x1) when
cases reflex to FISH
For more information about differences between NTRK testing
methods, please review the March 2020 webinar by Dr. Weiss: Testing
Methods to identify NTRK Gene Fusions Including NGS, FISH, and IHC.
Note: Interface
clients interested in ordering the new NTRK1-3 FISH reflex options should email
the interface team at InterfaceTeam@neogenomics.com
for ordering details.
Molecular
Effective Monday,
March 8th, NeoTYPE®
Endometrial Profile will now include testing for MLH1 Promoter Methylation.
- MLH1 promoter methylation analysis is useful to
distinguish sporadic from inherited endometrial cancer in tumors that are
MLH1-deficient by IHC staining and/or have high levels of microsatellite
instability (MSI-H).
- There are no changes to CPT Codes or turnaround times for this test addition.