Neogenomics Laboratories

NeoGenomics News

8/17/2022


 

Test Updates


IHC

Kappa ISH, Lambda ISH, and EBER ISH
Effective immediately - Due to a current backorder on kits used to stain these ISH markers, the following will be in place when testing is requested:

  • Kappa/Lambda ISH - We will be recommending Kappa IHC and Lambda IHC as alternative testing to ISH.
  • EBER ISH - Since there is no IHC alternative for this test, we will be notifying of the option to send out this stain.

We will provide additional communication as soon as any new information becomes available. We sincerely apologize for this inconvenience.

 

Molecular

IDH1 & IDH2 Mutation Analysis
Effective Monday, August 29th, the following changes will be implemented for this test:

  • Methodology: the test will be performed by real-time PCR instead of bi-directional sequencing for better sensitivity. IDH1 and IDH2 will be analyzed concurrently for detection of mutations at IDH1 codons R132X and R100Q and at IDH2 codons R140X and R172X
  • TAT will improve to 5 days from 7 days.
  • Test name will change to IDH1/IDH2 Mutation Analysis by PCR.
  • This change in methodology will also apply to the IDH1/IDH2 analysis included in the Rapid AML Therapeutic Panel.
  • No changes to CPT codes* and pricing.
  • Interface clients: This test update will involve a change in test code. Please see the Interface Updates section for more details.

New Code

MIDH12MAPMOL

IDH1/IDH2 Mutation Analysis by PCR

Discontinued Test

4044XMOL

IDH1 & IDH2 Mutation Analysis

 

NeoTYPE® CLL Prognostic Profile
Effective Monday, August 29th, the following changes will be implemented for this profile:

  • IgVH Mutation Analysis will no longer be included in the profile by default. It will be available as an optional add-on to be ordered as needed.
  • Test name will change to NeoTYPE® CLL Profile
  • Test details will be updated as follows:
    • NGS (12 genes): ATM, BCL2, BIRC3, BTK, CARD11, CD79B, CXCR4, MYD88, NOTCH1, PLCG2, SF3B1, and TP53
    • FISH (6 probes): 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14)
    • Optional add-on: IgVH Mutation Analysis
  • Online Orders will appears as follows:
    • Online Orders 1.0 Version:
    • Online Orders 2.0 Version:
  • Paper requisition will list the test option as follows:
  • CPT codes* will change to 81450x1, 88374x4, and 81263x1( if IgVH is ordered) from 81450x1, 88374x4
  • Interface Clients: This change will involve new test codes. Please see the Interface Updates section for more details.

Existing Code

NCLLPNTP

NeoTYPE® CLL Profile

Existing Code

NCLLPMONTP

NeoTYPE® CLL Profile (Molecular Only)

Existing Code

NCLLPMONTP

NeoTYPE® CLL Profile (Tech Only FISH)

New Code

NCLLPPINTP

NeoTYPE® CLL Profile (plus IgVH Mutation Analysis)

New Code

NCLLPTOPINTP

NeoTYPE® CLL Profile (Tech Olny FISH, plus IgVH Mutation Analysis)

New Code

NCLLPMOPINTP

NeoTYPE® CLL Profile (Molecular Only, plus IgVH Mutation Analysis)

 

NeoTYPE® Follicular Lymphoma Profile
Effective Monday, August 29th, the following change will be implemented for this profile:

  • Methodology: BCL2 t(14;18) detection will be performed using fluorescence in situ hybridization (FISH) instead of fragment length analysis.
  • Test details will be updated as follows:
    • NGS (15 Genes): ARID1A, BCL2, BCL6, CDKN2A, CREBBP, EP300, EZH2, FAS, KMT2D, MAP2K1, MEF2B, PIK3CA, SOCS1, TNFAIP3, and TNFRSF14
    • FISH (3 probes): IgH/BCL2 t(14;18) | DUSP22-IRF4 (6p25.3) | TNFRSF14 (1p36)
  • CPT codes* will change to 81450x1, 88374x3 (or 88377x3) from 81450x1; 88374x2 (or 88377x2).
  • Pricing will be updated based on your pricing agreement with NeoGenomics for the addition of the FISH probe.
  • For Interface Clients: there are no changes in test codes.

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

 

Additional Announcement

NPI Lookup Feature - Online Orders, Interface Orders

Beginning Monday, August 29th, the NPI Lookup feature will now be available in Online Orders 1.0, similar to what exists today in Online Orders 2.0. This will allow for the search and selection of new and existing Ordering and/or Treating Physicians to be associated with client accounts. Having valid physician NPI information is imperative for proper report distribution and billing accuracy. It is highly recommended, and industry best practice, for an NPI to be provided with every order, including those placed via paper requisitions. Orders received without this information may result in a call for NPI verification (testing will not be delayed while obtaining NPI verification). For further details on the functionality of the NPI Lookup feature, please see the training that has been created here.

 

Interface Update

For interface-related test changes that will take effect on Monday August 28th, click here for a downloadable document to view the impacted interface test codes.


If you have interface questions, please contact InterfaceTeam@Neogenomics.com.