Neogenomics Laboratories

NeoGenomics News

2/12/2025
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February 12, 2025

   

FISH

Effective March 10th, the following FISH panels will be updated to better align with current guidelines, including WHO 2022 5th Edition Classification, and to facilitate more effective disease management for AML and MDS. These updates will be applicable to new cases accessioned on and after March 10. In-flight cases will not be affected.

AML Standard FISH Panel – Updates to the panel include:

  • Removal of the following probes:
    • 5q-, -5 (5p15, 5q31, 5q33)
    • 7q-, -7 (Cen 7, 7q22, 7q31)
    • Trisomy 8 (Cen 8)
    • 20q- (20q12, 20qter)
  • Addition of the following probe:
    • RPN1, MECOM (3q21, 3q26.2)
  • Availability of a reflex option:
    • Reflex to 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.

Future panel configuration:

  • Main panel: MLL (11q23) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16) | RPN1, MECOM (3q21, 3q26.2)
  • Optional Reflex panel: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.
  • Reflex results will be reported separately as AML Standard Reflex Panel.
  • CPT Codes*: 88374x5 automated. If reflex is added, add 88374x5.
 

MDS Standard FISH Panel – Updates to the panel include:

  • Removal of the following probe:
    • MLL (11q23)
  • Addition of the following probes:
    • p53 (17p13.1)/NF1 (17q11)
    • RPN1, MECOM (3q21, 3q26.2)
  • Availability of a reflex option:
    • Reflex to ETV6 (12p13) | MLL (11q23) | +19 (19p13.2, 19q13) when the main panel is negative.

Future panel configuration:

  • Main panel: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | 20q- (20q12, 20qter) | p53 (17p13.1)/NF1 (17q11) | RPN1, MECOM (3q21, 3q26.2) Note: +8 and 20q- are combined.
  • Optional Reflex panel: ETV6 (12p13) | MLL (11q23) | +19 (19p13.2, 19q13) when the main panel is negative.
  • Reflex results will be reported separately as MDS Standard Reflex Panel.
  • CPT Codes*: 88374x5 automated. If reflex is added, add 88374x3.

The FISH Signal Guide will be updated and available for download from NeoLINK under Documentation on March 10.

With the above panel updates, the following panels are projected to be discontinued, effective July 2025, to avoid redundancy in the HemeFISH portfolio. Follow-up reminders will be sent out regularly up to the official date of discontinuation.

  • AML Favorable Risk FISH Panel – Probes: RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16)
  • AML Non-Favorable Risk FISH Panel – Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33 | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | DEK/NUP214 (CAN) t(6;9) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2)
  • MDS Extended FISH Panel – Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | +19 (19p13.2, 19q13) | 20q- (20q12, 20qter)

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

 

 

Recently approved biomarkers– Claudin18.2

Claudin18 (CLDN18.2) is a new biomarker with an FDA-approved targeted therapy to treat gastric/GEJ cancer.

You can learn more by visiting our webpage.

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