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March 5, 2025

IDHNow for AML Sponsored Testing Program

Optimize your patient’s AML treatment with comprehensive molecular profiling.

AML is one of the most common forms of leukemia in adults, representing ~80% of all cases,¹ and up to 16% of patients may harbor an IDH1 mutation.² In fact, 85% of all AML cases have at least one somatic mutation.³

NeoGenomics has partnered with Servier to provide eligible AML patients a rapid IDH1/2 test by PCR with a 3-5 day turnaround to help you make informed treatment decisions. The program provides no-cost testing to eligible patients.

For more information and eligibility information, visit our website.

References:
1. Beaton M, Peterson GJ, O'Brien K. Acute Myeloid Leukemia: Advanced Practice Management. J Adv Pract Oncol. 2020;11(8):836-844. doi:10.6004/jadpro.2020.11.8.4.
2. Zarnegar-Lumley S, Alonzo TA, Gerbing RB, et al. IDH mutations in AML: a COG, SWOG, and ECOG analysis. Blood Adv. 2023;7(19):5941-5953. doi:10.1182/bloodadvances.2022008282.
3. Yu J, Li Y, Li T, et al. Gene mutational analysis in myelodysplastic syndrome and AML. Exp Hematol Oncol. 2020;9:2. doi:10.1186/s40164-019-0158-5.

FISH

Effective March 10th, the following FISH panels will be updated to better align with current guidelines, including WHO 2022 5th Edition Classification, and to facilitate more effective disease management for AML and MDS. These updates will be applicable to new cases accessioned on and after March 10. In-flight cases will not be affected.

AML Standard FISH Panel – Updates to the panel include:

• Removal of the following probes:
  • 5q-, -5 (5p15, 5q31, 5q33)
  • 7q-, -7 (Cen 7, 7q22, 7q31)
  • Trisomy 8 (Cen 8)
  • 20q- (20q12, 20qter)
• Addition of the following probe:
  • RPN1, MECOM (3q21, 3q26.2)
• Availability of a reflex option:
  • Reflex to 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.

Future panel configuration:

• Main panel: MLL (11q23) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | PML/RARA t(15;17) | CBFB inv(16), t(16;16) | RPN1, MECOM (3q21, 3q26.2)
• Optional Reflex panel: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.
• Reflex results will be reported separately as AML Standard Reflex Panel.
• CPT Codes*: 88374x5 automated. If reflex is added, add 88374x5.

 

MDS Standard FISH Panel – Updates to the panel include:

• Removal of the following probe:
  • MLL (11q23)
• Addition of the following probes:
  • p53 (17p13.1)/NF1 (17q11)
  • RPN1, MECOM (3q21, 3q26.2)
• Availability of a reflex option:
  • Reflex to ETV6 (12p13) | MLL (11q23) | +19 (19p13.2, 19q13) when the main panel is negative.

Future panel configuration:

• Main panel: 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | 20q- (20q12, 20qter) | p53 (17p13.1)/NF1 (17q11) | RPN1, MECOM (3q21, 3q26.2) Note: +8 and 20q- are combined.
• Optional Reflex panel: ETV6 (12p13) | MLL (11q23) | +19 (19p13.2, 19q13) when the main panel is negative.
• Reflex results will be reported separately as MDS Standard Reflex Panel.
• CPT Codes*: 88374x5 automated. If reflex is added, add 88374x3.

The FISH Signal Guide will be updated and available for download from NeoLINK under Documentation on March 10.

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.